Malegra 25 Mg | Dosages | Best Sildenafil @ 20%Off - Flatmeds
Malegra 25 Mg is a medication primarily used to treat erectile dysfunction (ED) in men. It contains sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor. The mechanism of action of sildenafil citrate in Malegra 25 Mg is similar to that of Sildenafil, as both medications contain the same active ingredient. Sildenafil citrate works by inhibiting the action of PDE5, an enzyme that degrades cGMP, a substance responsible for vasodilation in the penile tissues. When a man is sexually stimulated, nitric oxide is released in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. Guanylate cyclase catalyzes the production of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). Cyclic GMP relaxes smooth muscles in blood vessels, allowing them to widen and increase blood flow to the penis. However, PDE5 breaks down cGMP, leading to a decrease in blood flow to the penis and difficulty in achieving or maintaining an erection. By inhibiting PDE5, sildenafil citrate in Malegra 25 Mg helps to maintain higher levels of cGMP, which results in prolonged vasodilation and increased blood flow to the erectile tissue, facilitating an erection.