What to Know About Fioricet’s Med Interaction

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Fioricet, because it contains acetaminophen, butalbital, and caffeine, has potential interactions with other medications. It’s important to avoid combining Fioricet with other medications that contain acetaminophen, as this can lead to liver damage. Additionally, butalbital can interact with medications that depress the central nervous system, such as alcohol, sedatives, or benzodiazepines, leading to excessive sedation or respiratory depression.


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