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Codeine is an opioid analgesic that treats pain, diarrhea, and coughing. Codeine pills typically treat mild to acute degrees of pain. Codeine combinational medications such as codeine with acetaminophen (paracetamol) or codeine with an NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin or codeine with ibuprofen, may have more significant benefits than codeine itself.

Codeine is an oral medication with half an hour onset of action. It reaches peak concentration in the bloodstream within hours of intake. The therapeutic effects of codeine pills last for about four to six hours.