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Tramadol vs Oxycodone Tramadol and oxycodone are both prescription pain medications used to treat moderate to severe pain. However, there are some differences between the two: Potency: Oxycodone is considered to be a stronger pain reliever compared to tramadol, making it a more effective option for individuals with severe pain. Chemical structure: Oxycodone is a semi-synthetic opioid, while tramadol is a synthetic agonist that works on the central nervous system to relieve pain. Risk of dependence and abuse: Both oxycodone and tramadol have the potential for abuse and dependence, but oxycodone is considered to have a higher risk due to its potency and classification as a Schedule II controlled substance by the US Drug Enforcement Administration (DEA). Side effects: Oxycodone is more likely to cause side effects such as constipation, nausea, and drowsiness, while tramadol is more likely to cause headache, dizziness, and nausea. It's important to follow the prescription and dosing instructions given by a doctor and to not exceed the recommended dose. Both tramadol and oxycodone can have serious consequences if used improperly.