Letrozole
Femara Anti-Estrogen Steroids Letrozole For Women Breast Cancer Treatment and Muscle Building
Quick Detail:
Letrozole
Alias: Femara
CAS No: 112809-51-5
MF: C17H11N5
MW: 285.3
Purity: 98%
Appearance: white powder.
Description:
Letrozole is a powerful Aromatase Inhibitor that was developed to fight breast cancer. Femara(generic name is letrozole) is a new drug developed for the treatment of advanced breast cancer in women. Femara is the second in a new class of third-generation selective oral aromatase inhibitors.
Letrozole acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen.
Applications:
Letrozole is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Letrozole may also be used to treat infertility in women
Less serious side effects may include:
- hot flashes, warmth or redness in your face or chest;
- headache, muscle or joint pain;
- night sweats;
- weight gain;
- fatigue, feeling weak;
- nausea; or
- swelling in your hands, ankles, or feet.
Specifications:
Tests | Specifications | Results |
Appearance | White or off-white crystaline powder | White Crystalline powder |
Solubility | Soluble in Chloroform; Soluble in ethanol when heated | Conform |
ldentification | (1)Maximum absorption in wavelength of 240 nm Minimum absorption in wavelength of 215 nm | Conform Conform |
(2)Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
Melting points | 182?-184? | 182? |
Related substances | =0.5% | 0.3% |
Single impurity | =0.3% | 0.2% |
Loss on drying | =1.0% | 0.8% |
[Assay]C17H11N5 (On anhydrous basis) | =98.0% | 99.2% |
Conclusion | Conforms Specifications of Enterprise Standard. | |
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