IgM-mediated Pseudoallergy

New York,

https://non-igg-ab.creative-biolabs.com/the-mechanisms-and-implications-of-igm-mediated-pseudoallerg

A barrier to the practical application of nanomedicines such as PEGylated liposomes is IgM-mediated pseudoallergy. Engineering techniques to lower this risk of hypersensitivity have been guided by the elucidation of the molecular pathways involving complement activation and anti-PEG IgM. Safe, recurrent administration of medications using nanoparticles may be made possible by further developments to decrease IgM reactions or specifically eliminate anti-PEG IgM. Further comprehension of the pathways leading to pseudoallergy may potentially clarify other inexplicable infusion reactions to pegylated biopharmaceuticals.