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I'm just being very conservative big deal I encourage the use a rescue medication like plain old morphine or hydrocodone on the other hand to patients taking a drug known to induce method and metabolism that could increase methadone metabolism causing a reduced serum concentration so the dose I calculate Ripped Muscle X may be too low and the patient may have at pained now what do I do there I still go with a number I calculated I don't empirically increase the dose the method and I just strongly encourage the use or break your medication and then once the patient's steady-state them they can adjust the method and does.
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