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Tapentadol is a prescription medication used to treat moderate to severe pain. It is an opioid analgesic and acts on both the central nervous system's opioid receptors and norepinephrine reuptake inhibition. It is often prescribed for pain that is not adequately controlled by other pain relievers. Tapentadol Effective for the relief of moderate to severe acute pain, such as post-surgical pain or injury-related pain. It is Also used for the management of chronic pain conditions, including neuropathic pain associated with diabetic peripheral neuropathy.