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Boostaro What drugs are approved for weight loss?Six weight-loss drugs have been approved by the U.S. Food and Drug Administration (FDA) for long-term useBupropion-naltrexone (Contrave)Liraglutide (Saxenda)Orlistat (Xenical, Alli)Phentermine-topiramate (Qsymia)Semaglutide (Wegovy)Setmelanotide (Imcivree)Most prescription weight-loss drugs work by making you feel less hungry or fuller. Some do both. The exception is orlistat. It affects the way your body absorbs fat.Bupropion-naltrexoneBupropion-naltrexone is a combination drug. Naltrexone is used to treat alcohol and opioid addiction. Bupropion is a drug to treat depression, called an antidepressant, and a drug to help people stop smoking, called a quit-smoking aid. Like all antidepressants, bupropion carries a warning about suicide risk. Bupropion-naltrexone can raise blood pressure. So your provider will need to check your blood pressure regularly at the start of treatment. Common side effects include nausea, headache and constipation.LiraglutideLiraglutide also is used to manage diabetes. It's given as a daily shot. Nausea is a common complaint. Vomiting may limit its use.